A histamine H1 receptor antagonist (IC75 = 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum); protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs; prevents histamine-induced PCA in rabbits at 20 mg/kg; reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma

Chlorpheniramine (maleate) – 5 g

Brand:
Cayman
CAS:
113-92-8
Storage:
-20
UN-No:
Non-Hazardous - 2811 / 6.1

Chlorpheniramine is a histamine H1 receptor antagonist with an IC75 value of 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum.{39804} It protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs. Chlorpheniramine (20 mg/kg, i.p.) prevents histamine-induced passive cutaneous anaphylaxis (PCA) in rabbits.{39805} It also reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma.{39806} Formulations containing chlorpheniramine have been used in the treatment of seasonal allergies.  

 

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Description

A histamine H1 receptor antagonist (IC75 = 0.0016 μg/ml for reversal of histamine-induced spasms in isolated guinea pig ileum); protects against intravenous histamine-induced death (PD50 = 0.15 mg/kg) and delays induction of aerosolized histamine-induced coughing (ED100sec = 0.44 mg/kg) in guinea pigs; prevents histamine-induced PCA in rabbits at 20 mg/kg; reduces respiratory resistance and hypersecretion of tracheobronchial fluid in a dog model of histamine-induced asthma ,

Formal name: γ-(4-chlorophenyl)-N,N-dimethyl-2-pyridinepropanamine, 2Z-butenedioate

Synonyms:  Chlorprophenpyridamine (maleate)|dl-Chlorpheniramine (maleate)

Molecular weight: 390.9

CAS: 113-92-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma

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