A macrolide-type antibiotic that inhibits pyruvate carboxylases from Bacillus

Chlorothricin – 5 mg

Brand:
Cayman
CAS:
34707-92-1
Storage:
-20
UN-No:
Non-Hazardous - /

Chlorothricin is a macrolide-type antibiotic that inhibits pyruvate carboxylases from Bacillus, Azotobacter, rat, and chicken, preventing the conversion of pyruvate to oxaloacetate (Ki or IC50 = 173, 500, 260, and 120 μM, respectively).{25076,25078} Chlorothricin also inhibits malate dehydrogenases MDH1 (cytoplasmic) and MDH2 (mitochondrial) from pig heart (IC50s = 1.3 and 0.065 mM, respectively), preventing the oxidation of malate to oxaloacetate.{25077}  

 

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Description

A macrolide-type antibiotic that inhibits pyruvate carboxylases from Bacillus, Azotobacter, rat, and chicken (Ki or IC50 = 173, 500, 260, and 120 μM, respectively); also inhibits MDH1 (cytoplasmic) and MDH2 (mitochondrial) (IC50s = 1.3 and 0.065 mM, respectively)

Formal name: (4S,4aS,6aR,11E,12aR,15R,16aS,21aR,21bR)-4-[[4-O-[3-O-(3-chloro-6-methoxy-2-methylbenzoyl)-2,6-dideoxy-β-D-arabino-hexopyranosyl]-2,6-dideoxy-β-D-arabino-hexopyranosyl]oxy]-1,2,3,4,4a,6a,7,8,9,10,12a,15,16,21,21a,21b-hexadecahydro-22-hydroxy-15,21a-dimethyl-18,21-dioxo-18H-16a, 19-metheno-16aH-benzo[e]naphtho[2,1-m][1,4]dioxacyclopentadecin-14-carboxylic acid

Synonyms:  Antibiotic K 818A

Molecular weight: 955.5

CAS: 34707-92-1

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Macrolides||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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