A broad-spectrum organochlorine fungicide; forms adducts with GST and enzyme cysteine residues leading to GST depletion and enzyme deactivation; inhibits the growth of fungi as well as Gram-positive and Gram-negative bacteria (MICs = 0.5-1.7 µg/ml); completely inhibits the growth of P. infestans

Chlorothalonil – 100 mg

Brand:
Cayman
CAS:
1897-45-6
Storage:
-20
UN-No:
- 2811 / 6.1

Chlorothalonil is a broad-spectrum organochlorine fungicide that forms adducts with glutathione (GST; Item No. 10007461) and cysteine residues on enzymes leading to GST depletion and enzyme deactivation, respectively.{41822} In vitro, it inhibits the growth of C. albicans and C. orbiculare fungi, S. aureus and B. cereus Gram-positive bacteria, and E. coli and P. aeruginosa Gram-negative bacteria (MICs = 0.7, 5, 1.3, 0.7, 0.5, and 1.7 µg/ml, respectively).{41823,41824} In vivo, chlorothalonil (100 µg/ml) completely inhibits the growth of P. infestans, the tomato late blight pathogen, on tomato plants.{41825} It is toxic to aquatic organisms, including species of fish, crustaceans, molluscs, and algae with tenth percentile of toxicity values of 25.23, 40.59, 0.69, and 3.94 µg/L, respectively, as well as to other aquatic invertebrates.{41826} Chlorothalonil is carcinogenic in animal models and induces neoplasms in the forestomach and kidneys of rats when administered at a dose of 3.8 mg/kg per day, but it is not genotoxic.{41827} Formulations containing chlorothalonil have been used as fungicides in agriculture.  

 

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Description

A broad-spectrum organochlorine fungicide; forms adducts with GST and enzyme cysteine residues leading to GST depletion and enzyme deactivation; inhibits the growth of fungi as well as Gram-positive and Gram-negative bacteria (MICs = 0.5-1.7 µg/ml); completely inhibits the growth of P. infestans, the tomato late blight pathogen, on tomato plants at 100 µg/ml; toxic to aquatic organisms, including species of fish, crustaceans, molluscs, and algae with tenth percentile of toxicity values of 25.23, 40.59, 0.69, and 3.94 µg/L, respectively; carcinogenic in animal models and induces neoplasms in the forestomach and kidneys of rats at 3.8 mg/kg per day, but it is not genotoxic

Formal name: 2,4,5,6-tetrachloro-1,3-benzenedicarbonitrile

Synonyms:  2,4,5,6-Tetrachloroisophthalonitrile

Molecular weight: 265.9

CAS: 1897-45-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Pesticides|Fungicides||Research Area|Cancer||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Infectious Disease|Fungal Diseases|Candidiasis||Research Area|Toxicology|Environmental|Agriculture

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