A photosensitizer with antitumor activity when used in conjunction with irradiation in mice (2.5-10 mg/kg

Chlorin e6 – 250 mg

Brand:
Cayman
CAS:
19660-77-6
Storage:
-20
UN-No:
Non-Hazardous - /

Chlorin e6 (Ce6) is a second-generation photosensitizer with antitumor activity when used in conjunction with irradiation. In a mouse model of implanted fibrosarcoma, Ce6 (2.5-10 mg/kg, i.v. with irradiation at 50-200 J/cm2) led to complete tumor loss following varying levels of irradiation.{33795} A formulation including Ce6 was tested in a Phase I clinical study for patients with bronchogenic early superficial squamous cell carcinoma with positive results (40 mg/m2, i.v. with laser irradiation at 100 J/cm2).{33832} The same dosing paradigm in a Phase II clinical trial for early stage lung cancer patients led to a complete response in 82.9% of patients.{33794} Ce6 has been examined as a nanotechnology drug delivery tool.{33793}  

 

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Description

A photosensitizer with antitumor activity when used in conjunction with irradiation in mice (2.5-10 mg/kg, i.v. with irradiation at 50-200 J/cm2) and in clinical trials (40 mg/m2, i.v. with laser irradiation at 100 J/cm2)

Formal name: (7S,8S)-3-carboxy-5-(carboxymethyl)-13-ethenyl-18-ethyl-7,8-dihydro-2,8,12,17-tetramethyl-21H,23H-porphine-7-propanoic acid

Synonyms:  Ce6

Molecular weight: 596.7

CAS: 19660-77-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cancer

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