An inducer of ferroptosis; induces ferroptosis

Chlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) – 50 mg

Brand:
Cayman
CAS:
39916-28-4
Storage:
-20
UN-No:
Non-Hazardous - /

Chlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) is an inducer of ferroptosis.{50243} It induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells when used at a concentration of 3 µM.{50243} Chlorido[N,N’-disalicylidene-1,2-phenylenediamine]iron(III) inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3, and 5 µM, respectively), as well as NALM-6 cells resistant to daunorubicin (Item No. 14159) and vincristine (Item No. 11764) when used at concentrations ranging from 0.04 to 0.125 µM.{45533}  

 

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Description

An inducer of ferroptosis; induces ferroptosis, but not apoptosis or necroptosis, in NB1 cancer cells at 3 µM; inhibits proliferation of BJAB, NALM-6, Jurkat, MelHO, and MCF-7 cancer cells (IC50s = 0.07, 2.5, 1.5, 3 and 5 µM), as well as daunorubicine- and vincristine-resistant NALM-6 cells at 0.04-0.125 µM

Formal name: (SP-5-13)-chloro[[2,2′-[1,2-phenylenebis[(nitrilo-κN)methylidyne]]bis[phenolato-κO]](2-)]-iron

Synonyms:  [N,N’-o-Phenylenebis(salicylideneaminato)]iron(III) Chloride|Iron Salophene Complex

Molecular weight: 405.6

CAS: 39916-28-4

Purity: ≥95%

Formulation: A crystalline solid

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