A bis(biguanide) antimicrobial disinfectant and antiseptic agent; inhibits growth of clinical MRSA isolates (MIC90 = 4 μg/ml); inhibits growth of canine MRSA

Chlorhexidine (acetate hydrate) – 25 g

Brand:
Cayman
CAS:
206986-79-0
Storage:
-20
UN-No:
Non-Hazardous - /

Chlorhexidine is a bis(biguanide) antimicrobial disinfectant and antiseptic agent.{47176} It inhibits growth of clinical methicillin-resistant S. aureus (MRSA) isolates (MIC90 = 4 μg/ml).{47177} It is also active against canine isolates of MRSA, methicillin-susceptible S. aureus (MSSA), methicillin-resistant S. pseudintermedius (MRSP), and methicillin-susceptible S. pseudintermedius (MSSP; MIC90s = 4, 2, 2, and 1 mg/L, respectively).{47178} Chlorhexidine inhibits growth of E. faecium strains (MICs = 1.2-19.6 μg/ml) and C. albicans (MIC = 5.15 μg/ml).{47179,47180} It generates cations that bind to and destabilize the bacterial cell wall to induce death.{47181} Chlorhexidine also completely inhibits matrix metalloproteinase-2 (MMP-2) and MMP-9 when used at concentrations of 0.0001 and 0.002%, respectively, in a gelatin degradation assay.{28418} Formulations containing chlorhexidine have been used in antiseptic wound dressings, mouthwash, and toothpaste.  

 

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SKU: 26924 - 25 g Category:

Description

A bis(biguanide) antimicrobial disinfectant and antiseptic agent; inhibits growth of clinical MRSA isolates (MIC90 = 4 μg/ml); inhibits growth of canine MRSA, MSSA, MRSP, and MSSP isolates (MIC90s = 4, 2, 2, and 1 mg/l, respectively); inhibits growth of E. faecium strains (MICs = 1.2-19.6 μg/ml) and of C. albicans (MIC = 5.15 μg/ml); inhibits MMP-2 and MMP-9 at 0.0001 and 0.002%, respectively

Formal name: N,N”-bis(4-chlorophenyl)-3,12-diimino-2,4,11,13-tetraazatetradecanediimidamide, diacetate, hydrate

Synonyms:  CHX

Molecular weight: 625.6

CAS: 206986-79-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Fungal Diseases|Candidiasis

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