A pyrrole pro-insecticide; metabolized in vivo into CL 303268; increases respiratory activity in vivo in German cockroaches at 1-10 µg/insect but not in vitro in Sf9 insect cells at 1-100 µM or isolated rat liver mitochondria; active against insects susceptible and resistant to pyrethroid and organophosphate insecticides

Chlorfenapyr – 100 mg

Brand:
Cayman
CAS:
122453-73-0
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Chlorfenapyr is a pyrrole pro-insecticide that is metabolized in vivo into CL 303268 by mixed function oxidases.{37590} Chlorfenapyr increases respiratory activity in German cockroaches when used at concentrations ranging from 1 to 10 µg per insect but has no effect on respiration in Sf9 cells when used at concentrations ranging from 1 to 100 µM and does not affect respiration in isolated rat liver mitochondria up to a concentration of 10 µM. Chlorfenapyr is active against a variety of insects including those susceptible and resistant to pyrethroid and organophosphate insecticides, including horn flies (H. irritans) as well as A. culicifacies and A. stephensi mosquitos that carry malaria (LC50s = 2-2.39% suspension impregnated on paper).{37591,37592} Chlorfenapyr is lethal to rats with LD50 values of 441 and 1,152 mg/kg for male and female rats, respectively.{37590} Formulations containing chlorfenapyr have been used to control termites and in agriculture to control various insects.  

 

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Description

A pyrrole pro-insecticide; metabolized in vivo into CL 303268; increases respiratory activity in vivo in German cockroaches at 1-10 µg/insect but not in vitro in Sf9 insect cells at 1-100 µM or isolated rat liver mitochondria; active against insects susceptible and resistant to pyrethroid and organophosphate insecticides, including mosquitoes that carry malaria (LC50s = 2-2.39% suspension impregnated on paper); lethal to rats (LD50s = 441 and 1,152 mg/kg for male and female rats, respectively)

Formal name: 4-bromo-2-(4-chlorophenyl)-1-(ethoxymethyl)-5-(trifluoromethyl)-1H-pyrrole-3-carbonitrile

Synonyms:  AC-303630

Molecular weight: 407.6

CAS: 122453-73-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Endocrinology & Metabolism

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