A histamine H1 receptor antagonist (Ki = 9 nM) that is effective against HCV (EC50 = 44 nM)

Chlorcyclizine (hydrochloride) – 500 mg

Brand:
Cayman
CAS:
14362-31-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Chlorcyclizine is a phenylpiperazine that acts as a histamine H1 receptor antagonist (Ki = 9 nM).{23220} It has also been shown to be effective against hepatitis C virus (HCV; EC50 = 44 nM in vitro), preventing viral entry into host cells.{30619} In chimeric mice engrafted with primary human hepatocytes, 10-50 mg/kg chlorcyclizine significantly inhibited infection of HCV genotypes 1b and 2a.{30619}  

 

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Description

A histamine H1 receptor antagonist (Ki = 9 nM) that is effective against HCV (EC50 = 44 nM), preventing viral entry into host cells

Formal name: 1-[(4-chlorophenyl)phenylmethyl]-4-methyl-piperazine, monohydrochloride

Synonyms:  NSC 169496

Molecular weight: 337.3

CAS: 14362-31-3

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Entry/fusion Inhibitors||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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