An anthranilic diamide insecticide and ryanodine receptor agonist; stimulates release of calcium from intracellular stores in insects (EC50s= 40-50 nM for P. americana neurons and H. virescens or D. melanogaster recombinant ryanodine receptors); selective for insect over mammalian ryanodine receptors (EC50s = 14

Chlorantraniliprole – 10 mg

Brand:
Cayman
CAS:
500008-45-7
Storage:
-20
UN-No:
De Minimis - 3077 / 9

Chlorantraniliprole is an anthranilic diamide insecticide and agonist of ryanodine receptors located on the sarcoplasmic reticulum in muscle and endoplasmic reticulum in non-muscle cells.{43108} It binds to a different site than ryanodine on the receptor and stimulates the release of calcium from intracellular stores with EC50 values ranging from 40 to 50 nM for P. americana neurons and H. virescens or D. melanogaster recombinant ryanodine receptors. It is highly selective for insect over mammalian ryanodine receptors (EC50s = 14,000 nM, >100 µM, and >100 µM for C2C12 mouse, PC12 rat, and IMR32 human cells, respectively).{43109} Chlorantraniliprole is active against insects of the order Lepidoptera, including larvae of the fall armyworm (S. frugiperda), diamondback moth (P. xylostella), and tobacco budworm (H. virescens) with EC50 values of 0.02, 0.01, and 0.05 ppm, respectively, and of the orders Coleoptera, Diptera, and Isoptera. Formulations containing chlorantraniliprole have been used in agriculture to control moths, beetles, and caterpillars among other insects.  

 

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Description

An anthranilic diamide insecticide and ryanodine receptor agonist; stimulates release of calcium from intracellular stores in insects (EC50s= 40-50 nM for P. americana neurons and H. virescens or D. melanogaster recombinant ryanodine receptors); selective for insect over mammalian ryanodine receptors (EC50s = 14,000 nM, >100 µM, and >100 µM for C2C12 mouse, PC12 rat, and IMR32 human cells, respectively); active against larvae of the order Lepidoptera (EC50s = 0.02, 0.01, and 0.05 ppm for the fall armyworm, diamondback moth, and tobacco budworm, respectively)

Formal name: 3-bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide

Synonyms:  DPX-E 2Y45

Molecular weight: 483.1

CAS: 500008-45-7

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Cell Biology||Research Area|Toxicology|Environmental|Agriculture

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