A prodrug form of chloramphenicol; a substrate for SDH; is oxidized by human liver and rat liver and kidney mitochondria to release chloramphenicol in vitro; reduces human leukocyte migration in vitro; reduces E. coli growth in rabbit and rat models of pyelonephritis at 150 and 200 mg/kg

Chloramphenicol Succinate – 5 mg

Brand:
Cayman
CAS:
3544-94-3
Storage:
-20
UN-No:
Non-Hazardous - /

Chloramphenicol succinate is a water-soluble prodrug form of the antibiotic chloramphenicol.{36717} It is a substrate for succinate dehydrogenase (SDH) and is oxidized by human liver and rat liver and kidney mitochondria to release chloramphenicol in vitro.{36718} Chloramphenicol succinate reduces human leukocyte migration in vitro.{36719} In vivo, chloramphenicol succinate reduces E. coli growth in rabbit and rat models of pyelonephritis when administered at doses of 150 and 200 mg/kg, respectively.{36720} Chloramphenicol succinate (20 mg/kg) reduces infarct size in a porcine model of myocardial ischemia-reperfusion injury.{36721} Formulations containing chloramphenicol succinate have been used in the treatment of severe bacterial infections.  

 

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SKU: 25453 - 5 mg Category:

Description

A prodrug form of chloramphenicol; a substrate for SDH; is oxidized by human liver and rat liver and kidney mitochondria to release chloramphenicol in vitro; reduces human leukocyte migration in vitro; reduces E. coli growth in rabbit and rat models of pyelonephritis at 150 and 200 mg/kg, respectively; reduces infarct size in a porcine model of myocardial ischemia-reperfusion injury at 20 mg/kg

Formal name: butanedioic acid, mono[(2R,3R)-2-[(dichloroacetyl)amino]-3-hydroxy-3-(4-nitrophenyl)propyl] ester

Synonyms: 

Molecular weight: 423.2

CAS: 3544-94-3

Purity: ≥99%

Formulation: A solid

Product Type|Biochemicals|Antibiotics|Amphenicols||Research Area|Cardiovascular System|Cardiovascular Diseases|Myocardial Infarction||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Bacterial Diseases

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