A HDAC inhibitor; selective for HDAC1 over HDAC6 (IC50s = 0.15 and 1

Chlamydocin – 1 mg

Brand:
Cayman
CAS:
53342-16-8
Storage:
-20
UN-No:
Non-Hazardous - /

Chlamydocin is a histone deacetylase (HDAC) inhibitor that was originally isolated from D. chlamydosporia and has anticancer properties.{49276} It is selective for HDAC1 over HDAC6 (IC50 = 0.15 and 1,100 nM, respectively).{49277} Chlamydocin increases acetylation of histone H3 and histone H4 in A2780 cells when used at concentrations ranging from 1 to 1,000 nM.{49276} It inhibits growth of A2780, Malme-3M, MCF-7, HT-29, and HeLa cancer cells (IC50s = 0.36, 45, 5.3, 4.3, and 14 nM, respectively). Chlamydocin increases lifespan by 10% in a P185 mouse allograft model when administered at doses ranging from 20 to 160 mg/kg.{49278}  

 

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SKU: 28468 - 1 mg Category:

Description

A HDAC inhibitor; selective for HDAC1 over HDAC6 (IC50s = 0.15 and 1,100 nM, respectively); increases acetylation of histone H3 and histone H4 in A2780 cells at 1-1,000 nM; inhibits growth of A2780, Malme-3M, MCF-7, HT-29, and HeLa cancer cells (IC50s = 0.36, 45, 5.3, 4.3, and 14 nM, respectively); increases lifespan by 10% in a P185 mouse allograft model at 20-160 mg/kg

Formal name: cyclo[2-methylalanyl-L-phenylalanyl-D-prolyl-(αS,2S)-α-amino-η-oxo-2-oxiraneoctanoyl]

Synonyms: 

Molecular weight: 526.6

CAS: 53342-16-8

Purity: ≥70%

Formulation: A solid

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