A selective

Chk2 Inhibitor II – 5 mg

Brand:
Cayman
CAS:
516480-79-8
Storage:
-20
UN-No:
Non-Hazardous - /

Chk2 inhibitor II is a selective, ATP-competitive inhibitor of the DNA damage control kinase, checkpoint kinase 2 (IC50 = 15 nM).{28503} It has been shown to prevent apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 µM).{28503} This compound has been used to target the role of Chk2 in cellular signaling in response to DNA damage.{28504}  

 

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Description

A selective, ATP-competitive inhibitor of the DNA damage control kinase, Chk2 (IC50 = 15 nM); prevents apoptosis in human T-cells exposed to ionizing radiation (EC50 = 3-7.6 µM)

Formal name: 2-[4-(4-chlorophenoxy)phenyl]-1H-benzimidazole-6-carboxamide

Synonyms:  BML-277|C 3742|Checkpoint Kinase 2 Inhibitor II

Molecular weight: 363.8

CAS: 516480-79-8

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|CK2||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Signaling||Research Area|Cancer|DNA Damage and Repair||Research Area|Cell Biology|Cell Cycle

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