An antibiotic and LpxC inhibitor (Kis = 1-1.7 nM in A. aeolicus); active against Gram-negative bacteria (MICs = 0.05

CHIR090 – 5 mg

Brand:
Cayman
CAS:
728865-23-4
Storage:
-20
UN-No:
De Minimis - 3077 / 9

CHIR090 is an antibiotic that inhibits LpxC, a deacetylase involved in the biosynthesis of LPS lipid A, with Ki values of 1-1.7 nM in A. aeolicus.{38249} It is active against Gram-negative bacteria with MIC values of 0.05, 0.78, and 0.10-6.25 mg/ml for E. coli, P. aeruginosa, and various B. multivorans (II) strains, respectively.{38247,38248} It is comparable in strength to ciprofloxacin (Item No. 14286) in disc assays.{38249}  

 

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Description

An antibiotic and LpxC inhibitor (Kis = 1-1.7 nM in A. aeolicus); active against Gram-negative bacteria (MICs = 0.05, 0.78, and 0.10-6.25 mg/ml for E. coli, P. aeruginosa, and various B. multivorans (II) strains, respectively); comparable in strength to ciprofloxacin in disc assays,

Formal name: N-[(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl]-4-[2-[4-(4-morpholinylmethyl)phenyl]ethynyl]-benzamide

Synonyms: 

Molecular weight: 437.5

CAS: 728865-23-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases

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