An HDAC inhibitor (IC50s = 0.095

Chidamide – 1 mg

Brand:
Cayman
CAS:
1616493-44-7
Storage:
-20
UN-No:
Non-Hazardous - /

Chidamide is an inhibitor of histone deacetylases (HDACs; IC50s = 0.095, 0.160, 0.067, 0.733, 0.078, and 0.432 µM for HDAC1-3, 8, 10, and 11, respectively).{53218} It is selective for these HDACs over HDAC4-7 and 9 (IC50s = >30 µM for all). Chidamide also inhibits nicotinamide phosphoribosyltransferase (Nampt; IC50 = 2.1 µM).{50976} It inhibits cell growth in a panel of 18 cancer cell lines (GI50s = 0.4-40 µM) but has no effect on the growth of non-cancerous CCC-HEK human fetal kidney or CCC-HEL human liver cells (GI50s = >100 µM).{53218} In vivo, tucidinostat (12.5, 25, and 50 mg/kg) reduces tumor growth in HCT-8, A549, BEL-7402, and MCF-7 mouse xenograft models.{53218}  

 

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Description

An HDAC inhibitor (IC50s = 0.095, 0.160, 0.067, 0.733, 0.078, and 0.432 µM for HDAC1-3, 8, 10, and 11, respectively); selective for these HDACs over HDAC4-7 and 9 (IC50s = >30 µM for all); inhibits Nampt (IC50 = 2.1 µM); inhibits cell growth in a panel of 18 cancer cell lines (GI50s = 0.4-40 µM); reduces tumor growth in HCT-8, A549, BEL-7402, and MCF-7 mouse xenograft models at 12.5, 25, and 50 mg/kg

Formal name: N-(2-amino-5-fluorophenyl)-4-[[[1-oxo-3-(3-pyridinyl)-2-propen-1-yl]amino]methyl]-benzamide

Synonyms:  CS 055|HBI 8000|Tucidinostat

Molecular weight: 390.4

CAS: 1616493-44-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Deacetylases||Research Area|Epigenetics, Transcription, & Translation|Erasers|Histone Deacetylation

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