A dicaffeoyl ester with diverse biological activities; reduces the viability of Caco-2 and HCT116 colorectal cancer cells from 50-200 μg/ml; inhibits the 3'-processing and DNA integration activities of HIV integrase (IC50s = 1.1 and 0.8 μM

Chicoric Acid – 25 mg

Brand:
Cayman
CAS:
70831-56-0
Storage:
-20
UN-No:
Non-Hazardous - /

Chicoric acid is a dicaffeoyl ester that has been found in C. intybus with diverse biological activities.{43186} Chicoric acid (50-200 μg/ml) dose-dependently reduces the viability of Caco-2 and HCT116 human colorectal cancer cells.{43182} It inhibits HIV integrase activities, including 3′-processing of a DNA oligonucleotide and integration with template DNA (IC50s = 1.1 and 0.8 μM, respectively).{43183} Chicoric acid (0.5-10 μM) noncompetitively inhibits integration of HIV DNA by HIV integrase and, at concentrations greater than or equal to 5 μM, inhibits HIV entry into H9 cells.{43184} Oral administration of chicoric acid (10 and 30 mg/kg) reduces hepatic lipid accumulation, lipid peroxidation, and fibrosis, inhibits production of pro-inflammatory cytokines and activation of NF-kB, and activates the AMPK signaling pathway in a mouse model of non-alcoholic steatohepatitis (NASH) induced by a methionine and choline-deficient diet.{43589} Chicoric acid (2 mg/kg) also reduces blood glucose levels by 54% in mice with streptozotocin-induced diabetes.{43185}  

 

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Description

A dicaffeoyl ester with diverse biological activities; reduces the viability of Caco-2 and HCT116 colorectal cancer cells from 50-200 μg/ml; inhibits the 3′-processing and DNA integration activities of HIV integrase (IC50s = 1.1 and 0.8 μM, respectively); inhibits HIV entry into H9 cells at 5 μM; oral administration reduces hepatic lipid accumulation, lipid peroxidation, and fibrosis, inhibits production of pro-inflammatory cytokines and activation of NF-kB, and activates the AMPK signaling pathway in a mouse model of NASH induced by a methionine and choline-deficient diet at 10 and 30 mg/kg; reduces blood glucose levels by 54% in mice with streptozotocin-induced diabetes at 2 mg/kg

Formal name: (2R,3R)-2,3-bis[[(2E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propen-1-yl]oxy]-butanedioic acid

Synonyms:  Dicaffeoyltartaric Acid|L-Chicoric Acid|NSC 99173

Molecular weight: 474.4

CAS: 70831-56-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals|Integrase Inhibitors||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|Nucleic Acid Turnover/Signaling||Research Area|Cancer|Cell Death||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|NAFLD & NASH||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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