Description
A modulator of γ-secretase; inhibits the secretion of Aβ42 in H4-APP695NL cells (IC50 = 41 µM); selectively inhibits secretion of Aβ42 over Aβ40 with 79% and 14% inhibition, respectively, at 100 µM; does not inhibit COX-1 or COX-2 at concentrations up to 100 and 500 µM, respectively; decreases plasma levels of Aβ42 in Tg2576 mice at 12.5 mg/kg per day for seven days; reduces the plaque area and number of plaques in the brain of hAPP mice at 375 ppm in the diet; decreases the distance traveled, but not the escape latency, in the Morris water maze in hAPP mice compared to hAPP animals administered a vehicle control
Formal name: 1-(3′,4′-dichloro-2-fluoro[1,1′-biphenyl]-4-yl)-cyclopropanecarboxylic acid
Synonyms: CS 1103|CSP1103|Itanapraced
Molecular weight: 325.2
CAS: 749269-83-8
Purity: ≥95%
Formulation: A solid
Product Type|Biochemicals||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease
