A natural product which acts as a small molecule inhibitor of HIF signaling

Chetomin – 1 mg

Brand:
Cayman
CAS:
1403-36-7
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Chetomin is a natural product isolated from Chaetomium species which has antibacterial and antifungal properties.{22491} It is a small molecule inhibitor of hypoxia-inducible factor (HIF) signaling, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations.{22490} Chetomin effectively attenuates the HIF pathway both in cells and in vivo, in mice.{22490} It inhibits HIF-dependant signaling, cell growth, and tumor growth in cancer cells and xenografts.{22490,22489}  

 

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Description

A natural product which acts as a small molecule inhibitor of HIF signaling, disrupting the binding of HIF-1α and HIF-2α to p300 at low nanomolar concentrations; effectively attenuates the HIF pathway both in cells and in vivo, in mice

Formal name: 2,3S,5aR,6,10bS,11-hexahydro-3-(hydroxymethyl)-10b-[(1S,4S)-3-[[4-(hydroxymethyl)-5,7-dimethyl-6,8-dioxo-2,3-dithia-5,7-diazabicyclo[2.2.2]oct-1-yl]methyl]-1H-indol-1-yl]-2-methyl-3,11aS-epidithio-11aH-pyrazino[1′,2′:1,5]pyrrolo[2,3-b]indole-1,4-dione

Synonyms:  NSC 289491

Molecular weight: 710.9

CAS: 1403-36-7

Purity: ≥95%

Formulation: An crystalline solid

Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Prolyl Hydroxylation Enzymes||Research Area|Cancer|Transcription Factors|HIF-1α||Research Area|Cancer|Tumor Microenvironment

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