An internal standard for the quantification of chenodeoxycholic acid by GC- or LC-MS

Chenodeoxycholic Acid-d4 – 10 mg

Brand:
Cayman
CAS:
99102-69-9
Storage:
-20
UN-No:
Non-Hazardous - /

Chenodeoxycholic acid-d4 (CDCA-d4) is intended for use as an internal standard for the quantification of CDCA (Item No. 10011286) by GC- or LC-MS. CDCA is a hydrophobic primary bile acid.{59331} It is formed from cholesterol in the liver via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. CDCA is a farnesoid X receptor (FXR) agonist that binds to FXRs in a TR-FRET assay (EC50 = 13 µM) and induces FXR transactivation in a reporter assay.{13291,9823} It induces transcription of the gene encoding the Nrf2 target glutamate cysteine ligase (GCL) in primary hepatocytes and HepG2 cells when used at concentrations ranging from 25 to 100 µM.{16793}  

 

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Description

An internal standard for the quantification of chenodeoxycholic acid by GC- or LC-MS

Formal name: 3α,7α-dihydroxy-5β-cholan-24-oic-2,2,4,4-d4 acid

Synonyms:  CDCA-d4

Molecular weight: 396.6

CAS: 99102-69-9

Purity: ≥95%

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs

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