A primary bile acid; an FXR agonist that binds to FXRs in a TR-FRET assay (EC50 = 13 µM) and induces FXR transactivation in a reporter assay; induces transcription of GCL in primary hepatocytes and HepG2 cells from 25-100 µM

Chenodeoxycholic Acid – 5 g

Brand:
Cayman
CAS:
474-25-9
Storage:
-20
UN-No:
Non-Hazardous - /

Chenodeoxycholic acid (CDCA) is a hydrophobic primary bile acid.{59331} It is formed from cholesterol in the liver via a multistep process catalyzed by the cytochrome P450 (CYP) isoforms CYP7A1, CYP8B1, and CYP27A1. CDCA is a farnesoid X receptor (FXR) agonist that binds to FXRs in a TR-FRET assay (EC50 = 13 µM) and induces FXR transactivation in a reporter assay.{13291,9823} It induces transcription of the gene encoding the Nrf2 target glutamate cysteine ligase (GCL) in primary hepatocytes and HepG2 cells when used at concentrations ranging from 25 to 100 µM.{16793}  

 

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SKU: 10011286 - 5 g Category:

Description

A primary bile acid; an FXR agonist that binds to FXRs in a TR-FRET assay (EC50 = 13 µM) and induces FXR transactivation in a reporter assay; induces transcription of GCL in primary hepatocytes and HepG2 cells from 25-100 µM

Formal name: (3α,5β,7α)-3,7-dihydroxy-cholan-24-oic acid

Synonyms:  Anthropodeoxycholic Acid|CDCA|Fluibil|Hekbilin|Kebilis|Ulmenide

Molecular weight: 392.6

CAS: 474-25-9

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Bile Acids & Microbiome||Research Area|Endocrinology & Metabolism|Hormones & Receptors|FXRs & LXRs

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