Description
Chemokine-Like Receptor 1 (CMKLR1) is a G protein-coupled receptor relevant to the cellular chemotaxis of dendritic cells and macrophages.{13210} This receptor is also expressed in brain, liver, lung, and kidney tissues.{13210,17561} Chemerin, or TIG2, has been identified as the natural ligand for this receptor.{17560} Resolvin E1 has also been identified as a ligand for CMKLR1, acting to dampen cellular responses to inflammation.{13210,17558,17559} Chemerin is an 18 kDa protein that plays a role in immunity, inflammation, chemotaxis, and has been identified as an adipokine.{15020,17557,17561} Human CMKLR1 shares 80% sequence homology with its mouse ortholog.{17560} The human receptor exists in two isoforms, differing only by two amino acids due to a premature stop codon. Isoform one has 363 amino acids and an expected molecular weight of 42.3 kDa. Cayman’s CMKLR1 polyclonal antibody recognizes the C-terminal region of the protein and cell permeabilization is recommended prior to whole cell staining.
Synonyms: CMKLR1|DEZ|GPCR ChemR23|Resolvin E1 Receptor
Immunogen: Synthetic peptide from the C-terminal region of human CMKLR1
Formulation: 500 μl of peptide affinity-purified antibody
Isotype:
Applications: FC, IF, IHC, and WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Flow Cytometry||Application|Immunofluorescence||Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cardiovascular System|Kidney & Renal Disease||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity
