A benzophenanthridine alkaloid; induces Bcl-2- and caspase-dependent apoptosis in HepG2 human liver carcinoma cells (LD50 = 12 µM) and in Jurkat human T cells at 1 µM; downregulates hTERT expression

Chelidonine – 10 mg

Brand:
Cayman
CAS:
476-32-4
Storage:
-20
UN-No:
Non-Hazardous - /

Chelidonine is a benzophenanthridine alkaloid that has been isolated from C. majus.{42238,42237} It induces Bcl-2- and caspase-dependent apoptosis in HepG2 human liver carcinoma cells with an LC50 value of 12 µM and in Jurkat human T cells when used at a concentration of 1 µM.{42238,42236} Chelidonine also downregulates hTERT expression in HepG2 cells, reduces telomerase activity, and induces cell senescence.{42238}  

 

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SKU: 25097 - 10 mg Category:

Description

A benzophenanthridine alkaloid; induces Bcl-2- and caspase-dependent apoptosis in HepG2 human liver carcinoma cells (LD50 = 12 µM) and in Jurkat human T cells at 1 µM; downregulates hTERT expression, reduces telomerase activity, and induces cell senescence in HepG2 cells ,

Formal name: 5bR,6S,7,12bS,13,14-hexahydro-13-methyl-[1,3]benzodioxolo[5,6-c]-1,3-dioxolo[4,5-i]phenanthridin-6-ol

Synonyms: 

Molecular weight: 353.4

CAS: 476-32-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer|Cell Death|Apoptosis

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