A pyran with diverse biological activities; inhibits rat brain glutamate decarboxylase (Ki = 1.2 μM); reduces serum IL-6 and TNF-α levels

Chelidonic Acid – 5 g

Brand:
Cayman
CAS:
99-32-1
Storage:
-20
UN-No:
Non-Hazardous - /

Chelidonic acid is a pyran that has been found in C. majus and has diverse biological activities.{61073,61074,61075} It inhibits rat brain glutamate decarboxylase (Ki = 1.2 μM).{61074} Chelidonic acid (20 mg/kg per day) reduces serum IL-6 and TNF-α levels, colonic COX-2 and prostaglandin E2 (PGE2; Item No. 14010) levels, and the disease activity index score in a mouse model of ulcerative colitis induced by dextran sulfate sodium (DSS; Item No. 23250).{61073} It inhibits ovalbumin challenge-induced decreases in spleen IFN-γ levels and increases in serum, spleen, and nasal mucosa IgE levels, spleen IL-4 levels, and nasal mucosa eosinophil and mast cell infiltration in a mouse model of ovalbumin-sensitized allergic rhinitis when administered at a dose of 2 mg/kg.{61075}  

 

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SKU: 31324 - 5 g Category:

Description

A pyran with diverse biological activities; inhibits rat brain glutamate decarboxylase (Ki = 1.2 μM); reduces serum IL-6 and TNF-α levels, colonic COX-2 and PGE2 levels, and the disease activity index score in a mouse model of DSS-induced ulcerative colitis at 20 mg/kg per day; inhibits ovalbumin challenge-induced decreases in spleen IFN-γ levels and increases in serum, spleen, and nasal mucosa IgE levels, spleen IL-4 levels, and nasal mucosa eosinophil and mast cell infiltration in a mouse model of ovalbumin-sensitized allergic rhinitis at 2 mg/kg

Formal name: 4-oxo-4H-pyran-2,6-dicarboxylic acid

Synonyms:  NSC 3979

Molecular weight: 184.1

CAS: 99-32-1

Purity: ≥95%

Formulation: A crystalline solid

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