A potent

Chelerythrine (chloride) – 5 mg

Brand:
Cayman
CAS:
3895-92-9
Storage:
-20
UN-No:
Non-Hazardous - /

Chelerythrine is a potent, cell permeable inhibitor of protein kinase C (IC50 = 660 nM) that does not inhibit tyrosine protein kinases, cAMP-dependent protein kinase, or calcium/calmodulin-dependent protein kinase.{20399} Chelerythrine also inhibits Bcl-xL function (IC50 = 1.5 μM) by displacing Bax binding, inducing apoptosis in several cancer cell lines.{20397} Chelerythrine can also have PKC-independent effects, activate p38 MAP kinase and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo.{20400,20398,20401,20402}  

 

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SKU: 11314 - 5 mg Category:

Description

A potent, cell permeable inhibitor of PKC (IC50 = 660 nM); also inhibits Bcl-xL function (IC50 = 1.5 μM), inducing apoptosis in several cancer cell lines; can have PKC-independent effects, activate p38 and JUNK signaling pathways, and induce apoptosis in cancer cells both in vitro and in vivo

Formal name: 1,2-dimethoxy-12-methyl-[1,3]benzodioxolo[5,6-c]phenanthridinium, monochloride

Synonyms:  Broussonpapyrine chloride|NSC 646662

Molecular weight: 383.8

CAS: 3895-92-9

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Small Molecule Activators|Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|PKC Signaling

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