Description
An ellagitannin with diverse biological activities; an inhibitor of PTPN9 and PTPN11 (IC50s = 34 and 37 nM, respectively); increases glucose uptake in 3T3-L1 preadipocytes at 5 µM; induces apoptosis of HL-60 and NB4 APL, but not K562 CML, cells (IC50s = 7.5, 5, and >60 µM, respectively); reduces glycer-AGE-induced ROS production in HUVECs at 25 µM; reduces glutamate-induced ROS production and cell death in HT22 mouse hippocampal cells; inhibits H+/K+-ATPase activity (IC50 = 65.01 µg/ml)
Formal name: 1,3,6-tris(3,4,5-trihydroxybenzoate) cyclic 2→2:4→1-ester with (2S)-[(3R,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid, β-D-glucopyranose
Synonyms: Eutannin|NSC 69862
Molecular weight: 956.7
CAS: 18942-26-2
Purity: ≥98%
Formulation: A crystalline solid
