An ellagitannin with diverse biological activities; an inhibitor of PTPN9 and PTPN11 (IC50s = 34 and 37 nM

Chebulinic Acid – 1 mg

Brand:
Cayman
CAS:
18942-26-2
Storage:
-20
UN-No:
Non-Hazardous - /

Chebulinic acid is an ellagitannin that has been found in T. chebula and has diverse biological activities.{57331,57332,60057,57333,57334} It is an inhibitor of protein tyrosine phosphatase non-receptor 9 (PTPN9) and PTPN11 (IC50s = 34 and 37 nM, respectively).{57332} Chebulinic acid (5 µM) increases glucose uptake in 3T3-L1 preadipocytes. It induces apoptosis of HL-60 and NB4 acute promyelocytic leukemia (APL), but not K562 chronic myelogenous leukemia (CML), cells (IC50s = 7.5, 5, and >60 µM, respectively).{57331} Chebulinic acid (25 µM) reduces the production of reactive oxygen species (ROS) induced by glyceraldehyde-related advanced glycation end products (glycer-AGEs) in human umbilical vein endothelial cells (HUVECs) and reduces glutamate-induced ROS production and cell death in HT22 mouse hippocampal cells.{60057,57333} It inhibits H+/K+-ATPase activity (IC50 = 65.01 µg/ml) and reduces free and total gastric acidity, as well as increases gastric mucin secretion, in various rat models of gastric ulcer.{57334}  

 

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SKU: 32554 - 1 mg Category:

Description

An ellagitannin with diverse biological activities; an inhibitor of PTPN9 and PTPN11 (IC50s = 34 and 37 nM, respectively); increases glucose uptake in 3T3-L1 preadipocytes at 5 µM; induces apoptosis of HL-60 and NB4 APL, but not K562 CML, cells (IC50s = 7.5, 5, and >60 µM, respectively); reduces glycer-AGE-induced ROS production in HUVECs at 25 µM; reduces glutamate-induced ROS production and cell death in HT22 mouse hippocampal cells; inhibits H+/K+-ATPase activity (IC50 = 65.01 µg/ml)

Formal name: 1,3,6-tris(3,4,5-trihydroxybenzoate) cyclic 2→2:4→1-ester with (2S)-[(3R,4S)-5-carboxy-3,4-dihydro-3,7,8-trihydroxy-2-oxo-2H-1-benzopyran-4-yl]butanedioic acid, β-D-glucopyranose

Synonyms:  Eutannin|NSC 69862

Molecular weight: 956.7

CAS: 18942-26-2

Purity: ≥98%

Formulation: A crystalline solid

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