A phenol with diverse biological activities; reduces glycer-AGE-induced production of ROS in HUVECs at 100 µg/ml; reduces glycer-AGE-induced adhesion of HUVECs to THP-1 monocytes; induces Nrf2 nuclear translocation and GSH synthesis and inhibits glycer-AGE-induced collagen accumulation in LX-2 hepatic stellate cells; increases serum insulin levels and reduces blood urea nitrogen levels

Chebulic Acid – 1 mg

Brand:
Cayman
CAS:
23725-05-5
Storage:
-20
UN-No:
Non-Hazardous - /

Chebulic acid is a phenol that has been found in T. chebular and has diverse biological activities.{60057,60058,60059} It reduces production of reactive oxygen species (ROS) in human umbilical vein endothelial cells (HUVECs) induced by glyceraldehyde-related advanced glycation end products (glycer-AGEs) when used at a concentration of 100 µg/ml.{60057} Chebulic acid reduces glycer-AGE-induced adhesion of HUVECs to THP-1 monocytes. It induces Nrf2 nuclear translocation and glutathione (GSH) synthesis and inhibits glycer-AGE-induced collagen accumulation, a marker of fibrosis, in LX-2 hepatic stellate cells.{60058} In vivo, chebulic acid (25 and 50 mg/kg) increases serum insulin levels and reduces blood urea nitrogen levels, proteinuria, albuminuria, and serum glucose levels in a diabetic rat model of ischemia-reperfusion-induced nephropathy.{60059}  

 

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SKU: 11829 - 1 mg Category:

Description

A phenol with diverse biological activities; reduces glycer-AGE-induced production of ROS in HUVECs at 100 µg/ml; reduces glycer-AGE-induced adhesion of HUVECs to THP-1 monocytes; induces Nrf2 nuclear translocation and GSH synthesis and inhibits glycer-AGE-induced collagen accumulation in LX-2 hepatic stellate cells; increases serum insulin levels and reduces blood urea nitrogen levels, proteinuria, albuminuria, and serum glucose levels in a diabetic rat model of ischemia-reperfusion-induced nephropathy at 25 and 50 mg/kg

Formal name: (2S)-[(3S,4S)-3-carboxy-3,4-dihydro-5,6,7-trihydroxy-1-oxo-1H-2-benzopyran-4-yl]-butanedioic acid

Synonyms:  (–)-Chebulic Acid

Molecular weight: 356.2

CAS: 23725-05-5

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cardiovascular System|Kidney & Renal Disease|Diabetic Nephropathy||Research Area|Cardiovascular System|Vasculature|Endothelium||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Carbohydrate Oxidation||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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