An antibiotic with diverse biological activites; inhibits growth of S. aureus

Chartreusin – 5 mg

Brand:
Cayman
CAS:
6377-18-0
Storage:
-20
UN-No:
Non-Hazardous - /

Chartreusin is an antibiotic originally isolated from S. chartreusis with diverse biological activities.{38764} It inhibits growth of S. aureus, B. subtilis, M. luteus, M. flavus, B. fragilis, C. difficile, C. perfringens, and P. acnes (MICs = 0.4-12.5 μg/ml).{38765} Chartreusin binds to DNA and induces electrophoretic shifts in both supercoiled and nicked plasmid DNA.{22198} It also inhibits strand-passing activity of topoisomerase II in a P4 unknotting assay. Chartreusin inhibits protein synthesis in chick embryo fibroblasts (CEFs) and mouse fibroblast 3T6 cells (IC50s = 7 and 70 μM, respectively).{38766} It is cytotoxic to human lung carcinoma A549 cells in vitro (IC50 = 95 nM) and increases median survival in P388 leukemia and B16 melanoma mouse tumor models when administered at a dose of 10 mg/kg per day.{38765,22198}  

 

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SKU: 23773 - 5 mg Category:

Description

An antibiotic with diverse biological activites; inhibits growth of S. aureus, B. subtilis, M. luteus, M. flavus, B. fragilis, C. difficile, C. perfringens, and P. acnes (MICs = 0.4-12.5 μg/ml); inhibits strand-passing activity of topoisomerase II in a P4 unknotting assay; inhibits protein synthesis in CEFs and 3T6 cells (IC50s = 7 and 70 μM, respectively); cytotoxic to human lung carcinoma A549 cells in vitro (IC50 = 95 nM); increases median survival in P388 leukemia and B16 melanoma mouse tumor models (10 mg/kg per day)

Formal name: 10-[[6-deoxy-2-O-(6-deoxy-3-O-methyl-α-D-galactopyranosyl)-β-D-galactopyranosyl]oxy]-6-hydroxy-1-methyl-benzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione

Synonyms:  Antibiotic X 465A|Lambdamycin|NSC 5159

Molecular weight: 640.6

CAS: 6377-18-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|Topoisomerase||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Food-borne Illnesses

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