Description
An antibiotic with diverse biological activites; inhibits growth of S. aureus, B. subtilis, M. luteus, M. flavus, B. fragilis, C. difficile, C. perfringens, and P. acnes (MICs = 0.4-12.5 μg/ml); inhibits strand-passing activity of topoisomerase II in a P4 unknotting assay; inhibits protein synthesis in CEFs and 3T6 cells (IC50s = 7 and 70 μM, respectively); cytotoxic to human lung carcinoma A549 cells in vitro (IC50 = 95 nM); increases median survival in P388 leukemia and B16 melanoma mouse tumor models (10 mg/kg per day)
Formal name: 10-[[6-deoxy-2-O-(6-deoxy-3-O-methyl-α-D-galactopyranosyl)-β-D-galactopyranosyl]oxy]-6-hydroxy-1-methyl-benzo[h][1]benzopyrano[5,4,3-cde][1]benzopyran-5,12-dione
Synonyms: Antibiotic X 465A|Lambdamycin|NSC 5159
Molecular weight: 640.6
CAS: 6377-18-0
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Small Molecule Inhibitors|Topoisomerases||Research Area|Cancer|Cell Death||Research Area|Cancer|DNA Damage and Repair|Topoisomerase||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Food-borne Illnesses
