A cytotoxic alkaloid; inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM

(–)-Chaetominine – 500 µg

Brand:
Cayman
CAS:
918659-56-0
Storage:
-20
UN-No:
Non-Hazardous - /

(–)-Chaetominine is a cytotoxic alkaloid originally isolated from Chaetomium sp. IFB-E015.{43151} It inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM, respectively). (–)-Chaetominine induces apoptosis of K562 cells via upregulation of the Bax/Bcl-2 ratio, decreasing mitochondrial membrane potential, inducing mitochondrial cytochrome C release, and activation of caspase-3 and caspase-9.{43152} It also decreases doxorubicin efflux mediated by multidrug resistance-associated protein 1 (MRP1) and restores sensitivity to doxorubicin (Item No. 15007) in resistant K562 cells.{43153}  

 

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Description

A cytotoxic alkaloid; inhibits the growth of K562 leukemia and SW1116 colon cancer cells (IC50s = 20 and 28 nM, respectively); induces apoptosis of K562 cells via upregulation of the Bax/Bcl-2 ratio, decreasing mitochondrial membrane potential, inducing cytochrome C release, and activation of caspase-3 and caspase-9; decreases MRP1-mediated doxorubicin efflux and restores sensitivity to doxorubicin in resistant K562 cells

Formal name: (2S,4R,5aS,9cS)-4,5,5a,9c-tetrahydro-5a-hydroxy-2-methyl-4-(4-oxo-3(4H)-quinazolinyl)-3H-2a,9b-diazacyclopenta[jk]fluorene-1,3(2H)-dione

Synonyms: 

Molecular weight: 402.4

CAS: 918659-56-0

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Natural Products|Alkaloids||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Multidrug Resistance

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