An orally available

CH5424802 – 1 mg

Brand:
Cayman
CAS:
1256580-46-7
Storage:
-20
UN-No:
Non-Hazardous - /

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase that promotes cell proliferation and blocks apoptosis. CH5424802 is an ATP-competitive inhibitor of ALK (IC50 = 1.9 nM) that also inhibits F1174L, R1275Q, and L1196M mutants of ALK (IC50s = 1.0, 3.5, and 1.6 nM, respectively).{29767,29756} It shows more than 500-fold selectivity for ALK over a panel of 24 other kinases.{29767} CH5424802 is orally available and inhibits the growth of tumors in mouse xenograft models of nonsmall cell lung cancer and anaplastic large-cell lymphoma.{29767}  

 

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Description

An orally available, selective inhibitor of ALK (IC50 = 1.9 nM) that also inhibits F1174L, R1275Q, and L1196M mutants of ALK (IC50s = 1.0, 3.5, and 1.6 nM, respectively); inhibits the growth of tumors in mouse xenograft models of nonsmall cell lung cancer and anaplastic large-cell lymphoma

Formal name: 9-ethyl-6,11-dihydro-6,6-dimethyl-8-[4-(4-morpholinyl)-1-piperidinyl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrile

Synonyms:  Alectinib|RO5424802

Molecular weight: 482.6

CAS: 1256580-46-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Other Receptor Tyrosine Kinases||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling

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