A potent

CH5183284 – 1 mg

Brand:
Cayman
CAS:
1265229-25-1
Storage:
-20
UN-No:
Non-Hazardous - /

CH5183284 is a potent, selective inhibitor of the kinase activity of fibroblast growth factor receptors (FGFRs) 1, 2, and 3 (IC50s = 9.3, 7.6, and 22 nM, respectively).{27812} It less potently inhibits FGFR4 and platelet-derived growth factor receptor β (IC50s = 290 and 560 nM, respectively) and displays IC50 values greater than 1 µM for a diverse panel of tyrosine and serine/threonine kinases.{27812} CH5183284 is effective against FGFR2 containing the gatekeeper mutation V564F.{27812} Moreover, it inhibits the growth of cancer cells expressing FGFR genetic alterations both in vitro and in xenograft mouse models.{27812}  

 

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Description

A potent, selective inhibitor of the kinase activity of fibroblast growth factor receptors (FGFRs) 1, 2, and 3 (IC50s = 9.3, 7.6, and 22 nM, respectively); inhibits the growth of cancer cells expressing FGFR genetic alterations both in vitro and in xenograft mouse models

Formal name: [5-amino-1-(2-methyl-1H-benzimidazol-6-yl)-1H-pyrazol-4-yl]-1H-indol-2-yl-methanone

Synonyms:  Debio 1347

Molecular weight: 356.4

CAS: 1265229-25-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|FGFR Family||Product Type|Biochemicals|Kinase Inhibitors|PDGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling

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