A potent and orally bioavailable Hsp90 inhibitor; inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro (IC50s = 89 and 66 nM

CH5138303 – 5 mg

Brand:
Cayman
CAS:
959763-06-5
Storage:
-20
UN-No:
Non-Hazardous - /

CH5138303 is a triazine Hsp90 inhibitor.{38060} CH5138303 binds to the N-terminus of Hsp90α (Kd = 0.52 nM) and inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro (IC50s = 89 and 66 nM, respectively). CH5138303 also inhibits growth of human NCI-N87 gastric cancer xenografts (ED50 = 3.9 mg/kg) and displays high oral bioavailability in mice.  

 

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Description

A potent and orally bioavailable Hsp90 inhibitor; inhibits growth of HCT116 and NCI-N87 human tumor cell lines in vitro (IC50s = 89 and 66 nM, respectively); inhibits growth of human NCI-N87 gastric cancer xenografts (ED50 = 3.9 mg/kg) ,

Formal name: 4-[[4-amino-6-(5-chloro-1H,3H-naphtho[1,8-cd]pyran-6-yl)-1,3,5-triazin-2-yl]thio]-butanamide

Synonyms: 

Molecular weight: 415.9

CAS: 959763-06-5

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Heat Shock Proteins||Research Area|Cancer||Research Area|Cell Biology|Cellular Chaperones

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