A potent and specific antagonist of AhR that blocks activation by TCDD (IC50 = 0.03 µM); prevents the induction of CYP1A1 by TCDD in HepG2 cells and in livers of mice; suppresses Th17 cell differentiation both in vitro and in vivo

CH 223191 – 50 mg

Brand:
Cayman
CAS:
301326-22-7
Storage:
-20
UN-No:
Non-Hazardous - /

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that up-regulates many xenobiotic metabolizing enzymes, particularly in response to planar aromatic hydrocarbons.{26362} CH 223191 is a potent and specific antagonist of AhR that blocks activation by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD, IC50 = 0.03 µM).{26363} It prevents the induction of cytochrome P450 1A1 by TCDD in HepG2 cells and in livers of mice.{26363} Through its effects on AhR, CH 223191 suppresses Th17 cell differentiation both in vitro and in vivo and alters the expression of homeobox transcription factors necessary for the differentiation of embryonic stem cells to cardiomyocytes.{26364,26361}  

 

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Description

A potent and specific antagonist of AhR that blocks activation by TCDD (IC50 = 0.03 µM); prevents the induction of CYP1A1 by TCDD in HepG2 cells and in livers of mice; suppresses Th17 cell differentiation both in vitro and in vivo

Formal name: 1-methyl-N-[2-methyl-4-[2-(2-methylphenyl)diazenyl]phenyl]-1H-pyrazole-5-carboxamide

Synonyms: 

Molecular weight: 333.4

CAS: 301326-22-7

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Cytochrome P450||Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Research Area|Cell Biology|Stem Cell Research|Differentiation||Research Area|Immunology & Inflammation|Adaptive Immunity||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Xenobiotic Sensing||Research Area|Toxicology|Environmental

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