An adenosine receptor antagonist (IC50s = 3.5

CGS 15943 – 50 mg

Brand:
Cayman
CAS:
104615-18-1
Storage:
-20
UN-No:
Non-Hazardous - /

CGS 15943 is an orally bioavailable non-xanthine antagonist at adenosine (A) receptors with IC50 values of 3.5, 4.2, 16, and 51 nM in CHO cells transfected with human recombinant A1, A2A, A2B, and A3 receptors, respectively.{34118,39224} It also binds to the phosphatidylinositol 3-kinase (PI3K) catalytic subunit p110γ, and it inhibits proliferation of HCC hepatocellular carcinoma and PDAC pancreatic cancer adenocarcinoma cells through the PI3K/Akt signaling pathway.{39223} In rats, CGS 15943 (0.1-10 mg/kg, i.p.) increases locomotor activity in a dose-dependent manner.{39225} It also reinforces and reinstates cocaine-seeking in baboons through an adenosine-dependent mechanism.{39226}  

 

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Description

An adenosine receptor antagonist (IC50s = 3.5, 4.2, 16, and 51 nM for human recombinant A1, A2A, A2B, and A3 receptors); binds p100γ and inhibits proliferation of HCC and PDAC cells through the PI3K/Akt signaling pathway; increases locomotor activity in rats in a dose-dependent manner; reinforces and reinstates cocaine-seeking in baboons,

Formal name: 9-chloro-2-(2-furanyl)-[1,2,4]triazolo[1,5-c]quinazolin-5-amine

Synonyms:  CGS 15943A

Molecular weight: 285.7

CAS: 104615-18-1

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Neuroscience|Behavioral Neuroscience|Addiction Research

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