An inhibitor of Src family kinases that blocks the phosphorylation of peptide substrates and autophosphorylation of purified c-Src (IC50s = 5-20 and 40 nM

CGP 77675 – 1 mg

Brand:
Cayman
CAS:
234772-64-6
Storage:
-20
UN-No:
Non-Hazardous - /

CGP 77675 is an inhibitor of Src family kinases (SFKs) that blocks the phosphorylation of peptide substrates and autophosphorylation of purified c-Src (IC50s = 5-20 and 40 nM, respectively).{33451} It also inhibits the SFKs Lck and c-Yes with low nanomolar IC50 values.{33451,33450,33453} CGP 77675 is used to elucidate the role of SFKs in such processes as bone resorption, tight junction formation in epithelial cells, and allograft survival.{33450,33451,33454} It can also be used in combination with the GSK3 inhibitor CHIR99021 (Item No. 13122) to maintain mouse embryonic stem cells.{33452}  

 

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Description

An inhibitor of Src family kinases that blocks the phosphorylation of peptide substrates and autophosphorylation of purified c-Src (IC50s = 5-20 and 40 nM, respectively); also inhibits Lck and c-Yes with low nanomolar IC50 values

Formal name: 1-[2-[4-[4-amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]ethyl]-4-piperidinol

Synonyms: 

Molecular weight: 443.5

CAS: 234772-64-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling||Research Area|Cell Biology|ECM & Adhesion Molecules||Research Area|Cell Biology|Stem Cell Research

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