An antagonist of NPY receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay); selective for Y5 over Y1

CGP 71683 (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
192322-50-2
Storage:
-20
UN-No:
Non-Hazardous - /

CGP 71683 is an antagonist of neuropeptide Y (NPY) receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay).{52105} It is selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively). It inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration when used at a concentration of 0.25 μM.{52104} CGP 71683 (10 mg/kg, i.p.) inhibits increases in food intake induced by intracerebroventricular administration of NPY in rats.{52105}  

 

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Description

An antagonist of NPY receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay); selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively); inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration at 0.25 μM; inhibits increases in food intake induced by intracerebroventricular administration of NPY in rats at 10 mg/kg, i.p.

Formal name: N-[[trans-4-[[(4-amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide, monohydrochloride

Synonyms:  CGP 71683A

Molecular weight: 512.1

CAS: 192322-50-2

Purity: ≥98%

Formulation: A crystalline solid

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