Description
An antagonist of NPY receptor Y5 (IC50 = 1.4 nM in a radioligand binding assay); selective for Y5 over Y1, Y2, and Y4 receptors (IC50s = 2,765, 7,187, and 5,637 nM, respectively); inhibits NPY-induced increases in BT-549 cell growth and MDA-MB-231 cell migration at 0.25 μM; inhibits increases in food intake induced by intracerebroventricular administration of NPY in rats at 10 mg/kg, i.p.
Formal name: N-[[trans-4-[[(4-amino-2-quinazolinyl)amino]methyl]cyclohexyl]methyl]-1-naphthalenesulfonamide, monohydrochloride
Synonyms: CGP 71683A
Molecular weight: 512.1
CAS: 192322-50-2
Purity: ≥98%
Formulation: A crystalline solid
