Description
A CDK inhibitor (IC50s = 0.017, 0.08, and 0.05 µM for Cdk1/cyclin B, Cdk2/cyclin A, and Cdk2/cyclin E, respectively); selective for these CDKs over Cdk4/cyclin D1 (IC50 = 0.7 µM) and a variety of other kinases but does inhibit PKCα and v-Abl (IC50s = 0.25 and 0.4 µM, respectively); inhibits proliferation of colon, breast, lung, prostate, and ovarian cancer cells (IC50s = 25-84, 21-280, 40 and 68, 17 and 20, and 18-38 nM, respectively); inhibits poly(I:C)-induced NF-κB nuclear translocation in J774.1 cells at 8 and 32 nM; reduces plasma IL-6 levels and increases survival in a mouse model of LPS-induced endotoxemia at 10 mg/kg
Formal name: 3-[[4-[2-[(3-chlorophenyl)amino]-4-pyrimidinyl]-2-pyridinyl]amino]-1-propanol
Synonyms:
Molecular weight: 355.8
CAS: 164658-13-3
Purity: ≥98%
Formulation: A solid