A GAPDH ligand; binds to purified recombinant rabbit muscle GAPDH using affinity purification; increases survival of trophically withdrawn PC12 cells

CGP 3466 (maleate) – 5 mg

Brand:
Cayman
CAS:
200189-97-5
Storage:
-20
UN-No:
Non-Hazardous - /

CGP 3466 is a GAPDH ligand.{37164,37165} Immobilized CGP 3466 binds to GAPDH from rat hippocampus extracts and to purified recombinant rabbit muscle GAPDH using affinity purification.{37165} CGP 3466 reduces PAJU cell apoptosis induced by rotenone (Item No. 13995). CGP 3466 dose-dependently increases survival of trophically withdrawn PC12 cells, decreases cytosine arabinoside-induced apoptosis of cerebellar granule cells, and increases the number of tyrosine hydroxylase-positive (TH+) mesencephalic dopaminergic neurons in vitro.{37164} Oral administration of CGP 3466 (0.14 mg/kg) increases the number of TH+ dopaminergic neurons in a rat model of Parkinson’s disease induced by MPTP. It also reduces delayed acquisition in the Morris maze in a 6-OHDA-treated rat model of Parkinson’s disease and increases survival in progressive motor neuronopathy (pmn) mice, a genetic model of amyotrophic lateral sclerosis (ALS). Formulations containing CGP 3466 are under clinical investigation for the treatment of Parkinson’s disease and ALS.{37166,37167}  

 

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SKU: 23362 - 5 mg Category:

Description

A GAPDH ligand; binds to purified recombinant rabbit muscle GAPDH using affinity purification; increases survival of trophically withdrawn PC12 cells, dose-dependently decreases cytosine arabinoside-induced apoptosis of cerebellar granule cells, and increases the number of TH+ mesencephalic dopaminergic neurons in vitro; increases the number of TH+ dopaminergic neurons in an MPTP-induced rat model of Parkinson’s disease; reduces delayed acquisition in the Morris maze in a 6-OHDA-treated rat model of Parkinson’s disease; increases survival in pmn mice

Formal name: N-methyl-N-2-propyn-1-yl-dibenz[b,f]oxepin-10-methanamine, (2Z)-2-butenedioate

Synonyms:  CGP 3466B

Molecular weight: 391.4

CAS: 200189-97-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory||Research Area|Neuroscience|Neurodegenerative Disorders|Parkinson’s Disease

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