Selectively and reversibly blocks the CFTR channel (Ki = 4.3 µM); reduces intestinal fluid secretion induced by cholera toxin; effective in cells in culture and also in nasal and intestinal epithelia in vivo

CFTR Inhibitor II – 5 mg

Brand:
Cayman
CAS:
328541-79-3
Storage:
-20
UN-No:
Non-Hazardous - /

The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR).{25612} CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (Ki = 4.3 µM).{25797,25798} This compound binds to a site at the external pore of CFTR, occluding the pore and rapidly preventing chloride transport.{25797,25798} Intraluminal CFTR inhibitor II greatly reduces intestinal fluid secretion induced by cholera toxin.{25798} It is effective in cells in culture and also in nasal and intestinal epithelia in vivo.{25794,25793,25795,25796}  

 

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Description

Selectively and reversibly blocks the CFTR channel (Ki = 4.3 µM); reduces intestinal fluid secretion induced by cholera toxin; effective in cells in culture and also in nasal and intestinal epithelia in vivo

Formal name: 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide N-2-naphthalenyl-glycine

Synonyms:  Cystic Fibrosis Transmembrane Conductance Regulator Inhibitor II|GlyH-101

Molecular weight: 493.2

CAS: 328541-79-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Ion Channel Modulation|Blockers||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Cholera

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