![A synthetic peptide GnRHR antagonist (Kd = 0.2 nM); inhibits [D-Trp6]GnRH-induced activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells (IC50 = 1.2 nM); reduces tumor volume and serum luteinizing hormone levels by 35% and 50% of control](https://interpriseusa.com/wp-content/uploads/2021/06/23910.png)
Description
A synthetic peptide GnRHR antagonist (Kd = 0.2 nM); inhibits [D-Trp6]GnRH-induced activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells (IC50 = 1.2 nM); reduces tumor volume and serum luteinizing hormone levels by 35% and 50% of control, respectively, in a human epithelial ovarian cancer mouse xenograft model at 60 μg per day; increases PMF survival in ovaries in cyclophosphamide treated mice at 0.5 mg/kg
Formal name: N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide, acetate
Synonyms: SB-75
Molecular weight: 1,431.10
CAS: 145672-81-7
Purity: ≥95%
Formulation: A solid
Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Reproductive Biology
