Cetrorelix (acetate) – 10 mg

Brand:
Cayman
CAS:
145672-81-7
Storage:
-20
UN-No:
Non-Hazardous - /

Cetrorelix is a synthetic peptide antagonist of the gonadotropin-releasing hormone receptor (GnRHR) with a Kd value of 0.2 nM for radioligand binding to murine LTK- cells expressing human GnRHR.{42016} It inhibits the activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells by the GnRHR agonist [D-Trp6]GnRH (IC50 = 1.2 nM). In vivo, cetrorelix (60 μg per day) reduces tumor volume to 35% of control and decreases serum luteinizing hormone levels by 50% in a human epithelial ovarian cancer mouse xenograft model.{42017} Centrorelix (0.5 mg/kg) protects the primordial follicles (PMF) in mouse ovaries from damage induced by cyclophosphamide (Item No. 13849) with 65% to 86% PMF survival compared to 46% PMF survival with a saline control.{42018} Formulations containing cetrorelix have been used to prevent ovulation during in vitro fertilization.  

 

Available on backorder

SKU: 23910 - 10 mg Category:

Description

A synthetic peptide GnRHR antagonist (Kd = 0.2 nM); inhibits [D-Trp6]GnRH-induced activation of hGnRHR and a downstream luciferase reporter gene in murine LTK- cells (IC50 = 1.2 nM); reduces tumor volume and serum luteinizing hormone levels by 35% and 50% of control, respectively, in a human epithelial ovarian cancer mouse xenograft model at 60 μg per day; increases PMF survival in ovaries in cyclophosphamide treated mice at 0.5 mg/kg


Formal name: N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-L-tyrosyl-N5-(aminocarbonyl)-D-ornithyl-L-leucyl-L-arginyl-L-prolyl-D-alaninamide, acetate

Synonyms:  SB-75

Molecular weight: 1,431.10

CAS: 145672-81-7

Purity: ≥95%

Formulation: A solid


Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Reproductive Biology