A pancreatic lipase inhibitor (IC50s = 5.95 and 54.8 nM for the human and rat enzymes

Cetilistat – 25 g

Brand:
Cayman
CAS:
282526-98-1
Storage:
-20
UN-No:
Non-Hazardous - /

Cetilistat is an inhibitor of pancreatic lipase (IC50s = 5.95 and 54.8 nM for the human and rat enzymes, respectively).{61090} It reduces increases in plasma triglyceride levels in an oral fat tolerance test, indicating decreased intestinal fat absorption, in rats when administered at a doses ranging from 3 to 100 mg/kg. Dietary administration of cetilistat (4.9-50.7 mg/kg per day) decreases body weight gain without affecting food intake, as well as reduces increases in plasma triglyceride and leptin levels in a rat model of high-fat diet-induced obesity. It also reduces viral load in the culture supernatant of Vero E6 cells infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; EC90 = 2.9 µM) and inhibits SARS-CoV-2 replication in a plaque reduction assay (EC50 = 1.13 µM).{59330}  

 

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SKU: 31622 - 25 g Category:

Description

A pancreatic lipase inhibitor (IC50s = 5.95 and 54.8 nM for the human and rat enzymes, respectively); reduces increases in plasma triglyceride levels in an oral fat tolerance test in rats from 3-100 mg/kg; decreases body weight gain without affecting food intake, as well as reduces increases in plasma triglyceride and leptin levels in a rat model of high-fat diet-induced obesity from 4.9-50.7 mg/kg per day; reduces viral load in the culture supernatant of Vero E6 cells infected with SARS-CoV-2 (EC90 = 2.9 µM) and inhibits SARS-CoV-2 replication in a plaque reduction assay (EC50 = 1.13 µM)

Formal name: 2-(hexadecyloxy)-6-methyl-4H-3,1-benzoxazin-4-one

Synonyms:  ATL-962

Molecular weight: 401.6

CAS: 282526-98-1

Purity: ≥95%

Formulation: A solid

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