An irreversible inhibitor of fatty acid synthase (FASN); causes cytoxicity and apoptosis in human cancer cell lines; causes weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice

Cerulenin – 5 mg

Brand:
Cayman
CAS:
17397-89-6
Storage:
-20
UN-No:
Non-Hazardous - /

A number of tumor cells and cell lines have been observed to have highly upregulated expression and activity of fatty acid synthase (FASN). Inhibition of FASN by the irreversible inhibitor cerulenin leads to cytotoxicity and apoptosis in human cancer cell lines,{11992} an effect believed to be mediated by the accumulation of malonyl-coenzyme A in cells with an upregulated FASN pathway.{11993} Cerulenin also leads to profound weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice.{7659}  

 

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Description

An irreversible inhibitor of fatty acid synthase (FASN); causes cytoxicity and apoptosis in human cancer cell lines; causes weight loss and feeding inhibition in both high-fat diet wild type obese and leptin-deficient ob/ob mice

Formal name: 2R,3S-epoxy-4-oxo-7,10-dodecadienamide

Synonyms: 

Molecular weight: 223.3

CAS: 17397-89-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Metabolism||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity

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