Description
An ergosterol fungal metabolite; active against the bacteria S. typhi, S. aureus, and E. faecalis (MICs = 25, 25, 50 µg/ml, respectively) and the fungus A. niger (MIC = 25 µg/ml), but has no effect on the bacteria E. coli, P. aeruginosa, S. pyogenes, K. pneumonia, and B. subtilis, or the fungi C. albicans, A. flavus, and A. tamarii at 400 µg/ml; inhibits LPS-induced increases in the levels of NO, TNF-α, IL-6, IL-10, and PGE2 in RAW 264.7 cells at 2-20 µM; inhibits proliferation of MCF-7, MDA-MB-231, and Caco-2 cancer cells (EC50s = 64.5, 52.4, and 37.6 µM, respectively), but not PC3, PANC-1, or A549 cells (IC50s = >100 µM for all)
Formal name: (3β,5α,6β,22E)-ergosta-7,22-diene-3,5,6-triol
Synonyms:
Molecular weight: 430.7
CAS: 516-37-0
Purity: ≥70%
Formulation: A solid
