An NMDA receptor antagonist (IC50 = 36 nM); selective for the NMDA receptor over sigma receptors (IC50 = 2

Cerestat – 5 mg

Brand:
Cayman
CAS:
137160-11-3
Storage:
-20
UN-No:
Non-Hazardous - /

Cerestat is an NMDA receptor antagonist (IC50 = 36 nM).{52616} It is selective for the NMDA receptor over sigma receptors (IC50 = 2,540 nM). Cerestat (1 mg/kg) reduces infarct volume and the number of steps and errors in a foot fault test in a rat model of stroke induced by middle cerebral artery occlusion.{52617} It also reduces cortical and striatal neuronal necrosis in a rat model of temporary focal ischemia when administered at a dose of 1.13 mg/kg.{52618}  

 

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Description

An NMDA receptor antagonist (IC50 = 36 nM); selective for the NMDA receptor over sigma receptors (IC50 = 2,540 nM); reduces infarct volume and the number of steps and errors in a foot fault test in a rat model of stroke induced by middle cerebral artery occlusion at 1 mg/kg; reduces cortical and striatal neuronal necrosis in a rat model of temporary focal ischemia at 1.13 mg/kg

Formal name: N-(3-ethylphenyl)-N-methyl-N′-1-naphthalenyl-guanidine, monohydrochloride

Synonyms:  CNS 1102

Molecular weight: 339.9

CAS: 137160-11-3

Purity: ≥98%

Formulation: A solid

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