A cytotoxic phytotoxin; produces ROS in plant hosts; has light-activated cytotoxic effects (CC50s = 241

Cercosporin – 1 mg

Brand:
Cayman
CAS:
35082-49-6
Storage:
-20
UN-No:
Non-Hazardous - /

Cercosporin is a pigmented phytotoxin isolated from the fungus C. kikuchii that produces reactive oxygen species in plant hosts leading to cellular damage.{37038,37041} It exhibits light-activated cytotoxic effects in vitro with cytotoxic concentration (CC50) values of 241, 282, and 174 nM in HeLa, A432, and MCF-7 cells, respectively.{37040} It is a selective inhibitor of PKC (IC50 = 600-1,300 nM) with no activity on PKA or PPK at concentrations over 180 µM.{37039}  

 

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Description

A cytotoxic phytotoxin; produces ROS in plant hosts; has light-activated cytotoxic effects (CC50s = 241, 282, and 174 nM in HeLa, A432, and MCF-7 cells, respectively); a selective inhibitor of PKC (IC50 = 600-1,300 nM) with no activity on PKA or PPK

Formal name: (13bR)-6,12-dihydroxy-8,9-bis[(2R)-2-hydroxypropyl]-7,10-dimethoxy-perylo[1,12-def]-1,3-dioxepin-5,11-dione

Synonyms:  CGP 049090|NSC 153111

Molecular weight: 534.5

CAS: 35082-49-6

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Natural Products|Microbial Metabolites||Product Type|Biochemicals|Ox Stress Reagents|Free Radical Generators||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Toxins||Research Area|Cancer|Cell Death||Research Area|Cancer|Cell Signaling|PKC Signaling||Research Area|Oxidative Stress & Reactive Species|Pro-oxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen||Research Area|Plant Biology|Phytotoxins

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