A natural antifungal phytotoxin that selectively and potently inhibits fungal Pkc1

Cercosporamide – 2.5 mg

Brand:
Cayman
CAS:
131436-22-1
Storage:
-20
UN-No:
Non-Hazardous - /

Cercosporamide is a natural antifungal phytotoxin isolated from the Cercosporidium fungus, which infects the leaves of cassava plants.{25074} Its antifungal effect results from its selective and potent inhibition of fungal PKC-like 1 kinases (Pkc1), which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1).{25072} Cercosporamide less effectively inhibits human PKC isoforms PKCα, β, and γ (IC50s = 1.02, 0.35, and 5.8 μM, respectively), an action linked to lowering of plasma glucose in hyperglycemic mice.{25072,25075} However, it potently inhibits MAPK-interacting kinases Mnk1 and Mnk2 (IC50 = 115 and 11 nM, respectively), reducing protein translation in cancer cells.{25071,25073} Cercosporamide is orally bioavailable.{25072,25075}  

 

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Description

A natural antifungal phytotoxin that selectively and potently inhibits fungal Pkc1, which are central to cell wall integrity (IC50 = 25 nM for Candida Pkc1); potently inhibits MAPK-interacting kinases Mnk1 and Mnk2 (IC50 = 115 and 11 nM, respectively), reducing protein translation in cancer cells

Formal name: (9aS)-8-acetyl-9,9a-dihydro-1,3,7-trihydroxy-9a-methyl-9-oxo-4-dibenzofurancarboxamide

Synonyms: 

Molecular weight: 331.3

CAS: 131436-22-1

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antifungals||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Kinase Inhibitors|PKC||Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Product Type|Biochemicals|Toxins||Research Area|Cancer|Cell Signaling|CaMK Signaling||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Infectious Disease|Fungal Diseases

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