A ceramidase inhibitor (IC50 = 28 μM for ceramidase activity in SKOV3 cells); increases intracellular accumulation of various ceramides and total ceramide levels and decreases levels of dihydrosphingosine

Ceranib-2 – 10 mg

Brand:
Cayman
CAS:
1402830-75-4
Storage:
-20
UN-No:
Non-Hazardous - /

Ceranib-2 is a ceramidase inhibitor that inhibits ceramidase activity (IC50 = 28 μM in SKOV3 cells).{19996} It also increases intracellular accumulation of various ceramides, including C14 ceramide (Item No. 22531), C24 ceramide (Item No. 62535), C26 ceramide, and C26:1 ceramide, and total ceramide levels and decreases levels of dihydrosphingosine, sphingosine, and sphingosine-1-phosphate (Item No. 22500) in SKOV3 cells. In vivo, ceranib-2 (20 and 50 mg/kg, i.p.) reduces tumor volume in a JC mammary adenocarcinoma mouse syngeneic tumor model.  

 

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SKU: 11092 - 10 mg Category:

Description

A ceramidase inhibitor (IC50 = 28 μM for ceramidase activity in SKOV3 cells); increases intracellular accumulation of various ceramides and total ceramide levels and decreases levels of dihydrosphingosine, sphingosine, and sphingosine-1-phosphate in SKOV3 cells; reduces tumor volume in a JC mammary adenocarcinoma mouse syngeneic tumor model at 20 and 50 mg/kg

Formal name: 3-[3-(4-methoxyphenyl)-1-oxo-2-propen-1-yl]-4-phenyl-2(1H)-quinolinone

Synonyms: 

Molecular weight: 381.4

CAS: 1402830-75-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sphingolipid Turnover||Research Area|Cancer

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