A biscoclaurine alkaloid that can decrease the fluidity of biological membranes; exhibits antiparasitic

Cepharanthine – 1 g

Brand:
Cayman
CAS:
481-49-2
Storage:
-20
UN-No:
Non-Hazardous - /

Cepharanthine is a biscoclaurine alkaloid extracted from S. cepharantha that is cationic and amphipathic and has been reported to decrease the fluidity of biological membranes.{31428} It exhibits antiparasitic, antimalarial, antiviral, anti-inflammatory, antimetastatic, and anticancer activities in various cell and animal models.{31428,31426,31429} Cepharanthine can decrease LPS-stimulated expression of TNF-α, IL-6, and IL-1β in macrophages and prevent the activation of NF-κB, ERK, JNK, and p38 MAPK.{31427} It has also been shown to inhibit cell and tumor growth, inducing G1 phase cell cycle arrest and apoptosis, and decreasing expression of STAT3, Bcl-xL, c-Myc, and cyclin D1 in osteosarcoma models.{31425}  

 

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Description

A biscoclaurine alkaloid that can decrease the fluidity of biological membranes; exhibits antiparasitic, antimalarial, antiviral, anti-inflammatory, antimetastatic, and anticancer activities in various cell and animal models

Formal name: 2,3,13,14,14aS,15,26,26aR-octahydro-22,30-dimethoxy-1,14-dimethyl-1H-4,6:16,19-dietheno-21,25-metheno-12H-[1,3]dioxolo[4,5-g]pyrido[2’,3’:17,18][1,10]dioxacycloeicosino[2,3,4-ij]isoquinoline

Synonyms:  NSC 623442|O-Methylcepharanoline

Molecular weight: 606.7

CAS: 481-49-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer|Cell Cycle|G1||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Signaling|JAK/STAT Signaling||Research Area|Cancer|Transcription Factors|STATs||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Parasitic Diseases|Malaria||Research Area|Infectious Disease|Viral Diseases

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